SMYRAF Tablets 50mg [Brand Name]

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Please read "Drug Information" before purchase.

Active ingredient
Peficitinib hydrobromide
Brand name medicine
SMYRAF
Effects of this medicine
・This medicine suppresses the action of several substances associated with expression of inflammation or pain by inhibiting the activity of an enzyme called Janus Kinase (JAK), thereby showing improvement on symptoms of rheumatoid arthritis such as pain or swelling of the joint.
・It is usually used for the treatment of patients with rheumatoid arthritis (including prevention of structural joint damage) who have not had shown enough efficacy with existing therapies.
Dosing schedule (How to take this medicine)
・In general, for adults, take 3 tablets (150 mg of peficitinib) at a time, once a day, after a meal. The dosage may be decreased to 2 tablets (100 mg) at a time, once a day, after a meal, according to the condition. If you have moderate liver dysfunction, take 1 tablet (50 mg) at a time, once a day, after a meal. Strictly follow the instructions.
・Before using this medicine, in addition to a medical interview and chest X-ray, blood test, and possibly a chest CT scan, should be performed to determine the presence of tuberculosis infection.
・Before using this medicine, blood test should be performed to determine the presence of hepatitis B virus infection and decrease in the number of blood cells.
・If you miss a dose, take the missed dose as soon as possible. However, if it is almost time for the next dose, skip the missed dose and follow your regular dosing schedule.
・You should never take two doses at one time.
Before using this medicine, be sure to tell your doctor and pharmacist
・If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines or foods.
・If you have: infections, active tuberculosis, liver dysfunction, neutropenia, lymphopenia, decreased hemoglobin, intestinal diverticulum (pouch-like cavity formed in the intestine), congenital short QT syndrome or a risk of venous thromboembolism.
・If you have or have a history of malignant tumor.
・If you have a history of interstitial pneumonia or herpes zoster.
・If you have a history of tuberculosis or are suspected to have tuberculous infection.
・If you are suspected to have or susceptible to infections.
・If you are a hepatitis B virus carrier or have a history of hepatitis B.
・If you are pregnant, possibly pregnant or breastfeeding.
・If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
Precautions while taking this medicine
・If you have any symptoms such as fever, dull, prolonged cough, skin abnormality and yellowing of the skin and the white of eyes, contact with your doctor before the next consultation day and see your doctor immediately.
・Chest X-ray or other examination should be performed periodically while you are using this medicine since you may develop tuberculosis.
・Blood test should be performed periodically while you are using this medicine since neutropenia, lymphopenia, decreased hemoglobin, abnormal lipid test value or liver dysfunction may occur.
・If you are a hepatitis B virus carrier or have been infected with hepatitis B virus in the past, examinations should be periodically performed since there is a risk of the reactivation of hepatitis B virus.
・Female patients with a possibility of getting pregnant should properly avoid pregnancy while using this medicine and at least 1 menstrual cycle after the completion of the therapy with this medicine.
・For healthcare professional use only
Storage conditions and other information
・Keep out of reach of children. Store at room temperature (1 to 30 degrees Celsius), away from direct sunlight and moisture.
・Discard the remainder. Do not store them. If you do not know how to discard, seek advice of your dispensing pharmacy or medical institution. Do not give the unused medicines to others.
・You should never receive live vaccines (for measles, rubella, mumps, chickenpox, etc., and BCG) during the treatment with this medicine since it may cause infection. If you need to receive preventive vaccination, be sure to consult with your doctor beforehand.